New research offers hope to neuro-tumor patients
Author: University of Plymouth
Published On: 07/10/2017
New research published 10 July in the journal Oncogene could offer hope to the thousands of, mainly young, people affected by the hereditary condition Neurofibromatosis 2 (NF2). This condition is characterised by the development of multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas, each associated with mutations in a gene coding for a tumour suppressor called Merlin.
In addition to NF2 disease there could be potential benefit for other cancers with the same mutations, including mesothelioma (usually linked to exposure to asbestos), breast cancer, colorectal carcinoma, melanoma, glioblastoma and spontaneous schwannomas and meningiomas occurring independently of NF2.
Scientists from the University of Plymouth and Plymouth Hospitals NHS Trust, supported by The Laura Crane Youth Cancer Trust and Brain Tumour Research, have revealed the role of the normal, cellular form of prion protein (PrPC) in the development of NF2-related tumours.
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