Awards for Transformative Research at Washington University

Author: NF Network, Washington University School of Medicine Neurofibromatosis Center

Published On: 09/11/25

At Washington University, a groundbreaking initiative is taking shape in the realm of pediatric healthcare, driven by the dedicated efforts of researchers in the Institute for Informatics, Data Science, and Biostatistics (I2DB). Dr. Aditi Gupta and her talented team have made significant strides in utilizing artificial intelligence (AI) and machine learning (ML) to develop models that can assess the risk of optic pathway gliomas (OPGs) in children with neurofibromatosis type 1 (NF1). This innovative approach is set to transform how NF1 is managed, leading to more personalized treatments and improved patient outcomes, while also alleviating the strain on healthcare resources. Recognizing the potential impact of her work, the Gilbert Family Foundation awarded Dr. Gupta a grant to create a large language model (LLM) designed to extract critical clinical and imaging information and validate these predictive models using real-world clinical data.

Meanwhile, in another part of the university, rising junior premed student Megan Ouyang is making her mark through her captivating research in the laboratory of Dr. David Gutmann. Megan recently received the prestigious Alex’s Lemonade Stand Foundation (ALSF) POST fellowship, which will support her continued investigations into the intricate relationship between the intestinal microbiota and pediatric brain tumor growth. Collaborating closely with Dr. Jit Chatterjee, a Senior Scientist in Neurology, Megan has uncovered fascinating evidence that specific gut bacteria might influence the growth of low-grade gliomas in mouse models.

As their paths parallel within the university, both Dr. Gupta and Megan Ouyang exemplify the spirit of innovation and dedication to advancing neurofibromatosis research. Their hard work not only stands as a testament to their individual contributions but also highlights the collaborative effort toward improving health outcomes for patients with NF. Congratulations are certainly in order for both, as their achievements foster hope and pave the way for groundbreaking advancements in medical science.

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